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Thymidylate synthase expression and genotype have no major impact on the clinical outcome of colorectal cancer patients treated with 5-fluorouracil

✍ Scribed by Marina Vignoli; Stefania Nobili; Cristina Napoli; Anna Laura Putignano; Maria Morganti; Laura Papi; Rosa Valanzano; Fabio Cianchi; Francesco Tonelli; Teresita Mazzei; Enrico Mini; Maurizio Genuardi


Book ID
119346886
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
488 KB
Volume
64
Category
Article
ISSN
1043-6618

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## Abstract Cytotoxic effect of 5‐fluorouracil 5‐FU is mediated through inhibition of thymidylate synthase (TS), and 5‐FU is catabolised by dihydropyrimidine dehydrogenase (DPD). Efficacy of 5‐FU may therefore depend on the TS and DPD activity of colorectal cancer. Archival tumour specimens from 30