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Thymic nurse cell clone supports the differentiation of CD4−8− thymocytes into CD4+8+ thymocytes in vitro

✍ Scribed by Xiuhua Gao; Takashi Nishimura; Yasuhiro Takeuchi; Tetsuo Sudo; Sonoko Habu

Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
713 KB
Volume
35
Category
Article
ISSN
0165-2478

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CD4+CD8+ thymocytes develop into CD4 or CD8 single-positive cells in athymic nude mice*
✍ Hidekazu Tamauchi; Norikazu Tamaoki; Sonoko Habu 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 English ⚖ 355 KB

A differentiation pathway from CD4+CD8+ cells to CD4+CD8- or CD4-CD8+ cells was investigated in athymic nude mice. Using fluorescence-activated cell sorter, CD4+CD8+ cells were sorted out from AKR thymocytes (H-2k, Thy-1.1) stained with two monoclonal antibodies against CD4 and CD8 (anti-L3T4 and an