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Thymic B-cell non-Hodgkin's lymphoma in a child

✍ Scribed by Azuma, Eiichi; Nishihara, Hidehiro; Qi, Jiang; Nagai, Masataka; Hiratake, Shinya; Zhang, Xiao-Li; Komada, Yoshihiro; Hamazaki, Minoru; Sakurai, Minoru

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
776 KB
Volume
57
Category
Article
ISSN
0361-8609

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✦ Synopsis

A 13-year-old male developed thymic non-Hodgkin's lymphoma. Microscopically, the tumor was composed of large cells, resembling centroblasts. Immunohistochemically, the tumor demonstrated leukocyte common antigen+, L26 (B-cell)+, UCHL1 (T-cell)-, suggesting the B-cell phenotype. In contrast to the terminally differentiated phenotype (CD10-, surface immunoglobulin-) observed in adult cases, flow cytometric analysis showed that they were relatively immature: CD10+, CD19+, HLA-DR-, IgM+/-, kappa+. He was successfully treated with intensive chemotherapy. Since childhood thymic lymphomas are exclusively small non-cleaved cell lymphoma with T-cell phenotype, this case represents a unique entity in children.

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