AGGRESSIVE NON-HODGKIN'S LYMPHOMA: T-CELL VERSUS B-CELL

✍ Scribed by RAYMOND LIANG; DAVID TODD; FAITH C. S. HO

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 364 KB
• Volume: 14
• Category: Article
• ISSN: 0278-0232
• DOI: 10.1002/(sici)1099-1069(199603)14:1<1::aid-hon555>3.0.co;2-y

✦ Synopsis

This study aimed to define the clinical characteristics, treatment outcome and independent prognostic factors of 144 patients with T-and 357 B-cell non-Hodgkin's lymphomas. Entities with well-defined immunophenotype and clinical characteristics were excluded. Patients with T-cell tumours were younger. T-immunophenotype was associated with more advanced disease and presence of B symptoms. They were also less likely to have bulky disease. Primary nasal lymphomas were usually T-cell while lymphomas arising from the gastrointestinal tract and Waldeyer's ring were mostly B-cell. On univariate analysis, T-immunophenotype was associated with lower CR rate, higher relapse rate and inferior overall survival. On the other hand, multivariate analysis revealed that advanced stage, presence of B symptoms, advanced age, high serum lactate dehydrogenase level and use of non-doxorubicin-containing regimens for induction were associated with poor prognosis. Immunophenotype was not a significant independent prognostic factor.