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Consecutive glioblastoma and B cell non-Hodgkin's lymphoma in a young child with von recklinghausen's neurofibromatosis

✍ Scribed by Uyttebroeck, Anne ;Legius, Eric ;Brock, Penelope ;Van De Casseye, Willy ;Casaer, Paul ;Van Daele, Maria Casteels

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
406 KB
Volume
24
Category
Article
ISSN
0098-1532

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✦ Synopsis

Abstract

A young child with neurofibromatosis type 1 (NF1) is reported who developed two primary malignancies: a glioblastoma, followed 6 months later by an abdominal B cell non‐Hodgkin's lymphoma. The child is now 4.5 years off treatment and disease free, but has developed progressive and severe psychomotor retardation as sequelae. The NF1 gene is known to act as a tumor suppressor gene. The possible mechanisms leading to the occurrence of a second primary tumor in this child are discussed. Β© 1995 Wiley‐Liss, Inc.

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