Angiogenesis and mast cell density with tryptase activity increase simultaneously with pathological progression in B-cell non-Hodgkin's lymphomas
✍ Scribed by Domenico Ribatti; Angelo Vacca; Andrea Marzullo; Beatrice Nico; Roberto Ria; Luisa Roncali; Franco Dammacco
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- French
- Weight
- 217 KB
- Volume
- 85
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
Node biopsies of 16 benign lymphadenopathies and 72 B-cell non-Hodgkin's lymphomas (B-NHLs) were investigated for counts of microvessels, total metachromatic mast cells (MCs) and MCs expressing tryptase, an angiogenesisinducing molecule. Counts were higher in B-NHLs. When grouped according to the Working Formulation (WF) malignancy grades, they were significantly higher in low-grade B-NHLs vs. lymphadenopathies and intermediate-grade vs. low-grade tumors and there was a further increase in the high-grade tumors. A high correlation was demonstrated in all groups of tissues between microvessel counts and both total metachromatic and tryptase-reactive MCs. These results suggest that angiogenesis in B-NHLs increases with their progression, and that MCs cooperate in its induction via the tryptase contained in their secretory granules. Int.