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Thrombosis in otherwise well children with the factor V Leiden mutation

✍ Scribed by Maria T. Sifontes; Rachelle Nuss; Linda J. Jacobson; John H. Griffin; Marilyn J. Manco-Johnson


Book ID
117165400
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
447 KB
Volume
128
Category
Article
ISSN
1097-6833

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To determine the prevalence of activated protein C resistance and the factor V Leiden mutation (position 1691, arginine 506 to glutamine substitution) in children with thrombosis, plasma samples from children with thrombosis were tested for activated protein C resistance. DNA was analyzed for the fa

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The factor V Leiden mutation in 12-children with thrombosis and in 20 controls was investigated. Five heterozygous individuals and 1 homozygous individual among the cases with thrombosis and 1 heterozygous individual among controls were found. Central nervous system thromboses were increased in chil