Acute promyelocytic leukemia is characterized by the reciprocal translocation of chromosomes 15 and 17. All-trans retinoic acid (ATRA) efficiently induces differentiation of the abnormal promyelocytes. In this study, we had used ATRA as the primary induction therapy for 17 newly diagnosed patients,
Thrombomodulin enhances the antifibrinolytic and antileukemic effects of all–trans retinoic acid in acute promyelocytic leukemia cells
✍ Scribed by Takayuki Ikezoe; Jing Yang; Chie Nishioka; Mayuka Isaka; Naomi Iwabu; Mizu Sakai; Ayuko Taniguchi; Goichi Honda; Akihito Yokoyama
- Book ID
- 113616803
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 792 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0301-472X
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📜 SIMILAR VOLUMES
## Abstract ## Background Due to severe side effects in virtually all children treated with a standard dose of 45 mg/m^2^/day all‐__trans__‐retinoic acid (ATRA) for acute promyelocytic leukemia (APL) the AML‐BFM study group reduced the dosage to 25 mg/m^2^/day. For the lack of data on the use of A
All trans-retinoic acid (ATRA) induces complete remission in acute-promyelocytic-leukemia (APL) patients. This study investigated the adhesive properties of APL cells for the endothelium and the extracellular matrix, their motility and the effect of ATRA on these functions. Blasts from 7 APL patient