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All-trans-retinoic acid induces tyrosine phosphorylation of the CrkL adapter in acute promyelocytic leukemia cells

✍ Scribed by Yazan Alsayed; Sanjiv Modi; Shahab Uddin; Nadim Mahmud; Brian J Druker; Eleanor N Fish; Ronald Hoffman; Leonidas C Platanias

Book ID: 114216145
Publisher: Elsevier Science
Year: 2000
Tongue: English
Weight: 341 KB
Volume: 28
Category: Article
ISSN: 0301-472X
DOI: 10.1016/s0301-472x(00)00170-3

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## Abstract ## Background Due to severe side effects in virtually all children treated with a standard dose of 45 mg/m^2^/day all‐__trans__‐retinoic acid (ATRA) for acute promyelocytic leukemia (APL) the AML‐BFM study group reduced the dosage to 25 mg/m^2^/day. For the lack of data on the use of A