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Thrombin induces cyclooxygenase-2 expression via the ERK and NF-κB pathways in human lung fibroblasts

✍ Scribed by Chung-Huang Shih; Mauo-Ying Bien; Ling-Ling Chiang; Chien-Ling Su; Chien-Huang Lin; Bing-Chang Chen

Book ID
113588372
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
767 KB
Volume
618
Category
Article
ISSN
0014-2999

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## Abstract Sphingosine 1‐phosphate (S1P) has been shown to regulate expression of several genes in vascular smooth muscle cells (VSMCs) and contributes to arteriosclerosis. However, the mechanisms regulating epidermal growth factor receptor (EGFR) expression by S1P in aortic VSMCs remain unclear.