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Activation of NFκB is necessary for IL-1β-induced cyclooxygenase-2 (COX-2) expression in human gingival fibroblasts

✍ Scribed by Sumi Nakao; Yorimasa Ogata; Emi Shimizu-Sasaki; Muneyoshi Yamazaki; Shunsuke Furuyama; Hiroshi Sugiya


Book ID
110248895
Publisher
Springer
Year
2000
Tongue
English
Weight
391 KB
Volume
209
Category
Article
ISSN
0300-8177

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Role of atypical protein kinase C isozym
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## Abstract Increased myometrial expression of cyclooxygenase‐2 (Cox‐2) at term results from elevated local levels of inflammatory cytokines, and its inhibition provides a potential route for intervention in human pre‐term labor. We have identified a role for atypical protein kinase C (PKC) isozyme