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Three rearrangements of chromosome 5 in a patient with myelodysplastic syndrome: an atypical deletion 5q, a complex intrachromosomal rearrangement of chromosome 5, and a paracentric inversion of chromosome 5

✍ Scribed by Nathalie Douet-Guilbert; Audrey Basinko; Jean-Richard Eveillard; Frédéric Morel; Marie-Josée Le Bris; Nadia Guéganic; Clément Bovo; Angèle Herry; Christian Berthou; Marc De Braekeleer


Book ID
119211564
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
598 KB
Volume
203
Category
Article
ISSN
0165-4608

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A newborn with Down syndrome was noted on the 1st day of life to have an elevated white blood cell count of 79,900/mm3 with 62% lymphoblasts and a platelet count of 61 ,000/mm3, consistent with either transient myeloproliferative disorder of Down syndrome (TMD) or acute leukemia. Karyotype analysis