This paper analyzes the hematologic features and outcome of 13 patients with chromosome 5 abnormalities (monosomy 5 or deletion of Sq), either isolated or with additional anomalies. Among four patients with isolated del (Sq), two had a stable refractory macrocytic anemia with thrombocytosis (Sqsyndr
Hematological features of patients with myelodysplastic syndromes associated with a chromosome 5q deletion
β Scribed by Dr. S. Lewis; D. Oscier; J. Boultwood; F. Ross; M. Fitchett; K. Rack; G. Abrahamson; V. Buckle; J. S. Wainscoat
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 687 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0361-8609
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A newborn with Down syndrome was noted on the 1st day of life to have an elevated white blood cell count of 79,900/mm3 with 62% lymphoblasts and a platelet count of 61 ,000/mm3, consistent with either transient myeloproliferative disorder of Down syndrome (TMD) or acute leukemia. Karyotype analysis
## Abstract Isolated deletions of the long arm of chromosome 5, del(5q), are observed in 10% of myelodysplastic syndromes (MDS) and are associated with a more favorable prognosis, although the clinical course varies considerably. If one or more additional chromosomal aberrations are present, this c