Three component coupling catalyzed by TaCl5–SiO2: synthesis of α-amino phosphonates
✍ Scribed by S Chandrasekhar; S.Jaya Prakash; V Jagadeshwar; Ch Narsihmulu
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- French
- Weight
- 85 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
TaCl 5 -SiO 2 has been utilized as an efficient Lewis acid catalyst for the three component coupling of carbonyl compounds, aromatic amines and diethyl phosphite to produce a-amino phosphonates.
📜 SIMILAR VOLUMES
A very mild, efficient and simple method for the synthesis of tertiary a-amino phosphonates is reported by reaction of an aldehyde, a secondary amine and trialkylphosphite in ethereal solution of lithium perchlorate, LPDE, at ambient temperature with high yields.
A simple, efficient, and environmentally benign method for a three-component reaction of an amine, an aldehyde or a ketone, and diethyl phosphite catalyzed by Amberlite-IR 120 resin has been developed to afford a-amino phosphonates in high yields and short reaction times under solvent-free reaction