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Amberlite-IR 120 catalyzed three-component synthesis of α-amino phosphonates in one-pot

✍ Scribed by Asish K. Bhattacharya; Kalpeshkumar C. Rana

Publisher
Elsevier Science
Year
2008
Tongue
French
Weight
148 KB
Volume
49
Category
Article
ISSN
0040-4039

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✦ Synopsis

A simple, efficient, and environmentally benign method for a three-component reaction of an amine, an aldehyde or a ketone, and diethyl phosphite catalyzed by Amberlite-IR 120 resin has been developed to afford a-amino phosphonates in high yields and short reaction times under solvent-free reaction conditions. The major advantages of the present method are good yields, inexpensive, ecofriendly and reusable catalyst, mild and solvent-free reaction conditions and tolerance towards various functionalities present in the substrates.

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