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Thorough QT Studies and Indirect Causes of QTc Changes

✍ Scribed by MALIK, MAREK; STOCKBRIDGE, NORMAN


Book ID
119879335
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
420 KB
Volume
35
Category
Article
ISSN
0147-8389

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## Introduction Dapagliflozin is a first-in-class sodium-glucose transporter 2 (SGLT2) inhibitor under investigation for the treatment of type 2 diabetes mellitus. A thorough QTc study was conducted, according to International Conference on Harmonization E14 guidelines, to characterize the effect o