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The Effect of Moxifloxacin on QTc and Implications for the Design of Thorough QT Studies

✍ Scribed by Bloomfield, DM; Kost, JT; Ghosh, K; Hreniuk, D; Hickey, LA; Guitierrez, MJ; Gottesdiener, K; Wagner, JA


Book ID
109845624
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
176 KB
Volume
84
Category
Article
ISSN
0009-9236

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## Introduction Dapagliflozin is a first-in-class sodium-glucose transporter 2 (SGLT2) inhibitor under investigation for the treatment of type 2 diabetes mellitus. A thorough QTc study was conducted, according to International Conference on Harmonization E14 guidelines, to characterize the effect o