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Evaluation of the Effects of AZD3480 on Cardiac Repolarization: A Thorough QT/QTc Study Using Moxifloxacin as a Positive Control

✍ Scribed by Dalén, P; Vik, T; Alverlind, S; Jostell, K-G; Hårdemark, H-G

Book ID
109846019
Publisher
Nature Publishing Group
Year
2010
Tongue
English
Weight
251 KB
Volume
88
Category
Article
ISSN
0009-9236

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## Introduction Dapagliflozin is a first-in-class sodium-glucose transporter 2 (SGLT2) inhibitor under investigation for the treatment of type 2 diabetes mellitus. A thorough QTc study was conducted, according to International Conference on Harmonization E14 guidelines, to characterize the effect o