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Thiopurine Methyltransferase in Red Blood Cells of Dogs, Cats, and Horses

✍ Scribed by Stephen D. White; Rod A.W. Rosychuk; Catherine A. Outerbridge; Kathryn V. Fieseler; Sharon Spier; Peter J. Ihrke; Phillip L. Chapman


Book ID
118093689
Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
32 KB
Volume
14
Category
Article
ISSN
0891-6640

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Thiopurine methyltransferase (TPMT) catalyzes thiopurine S-methylation, an important metabolic pathway for drugs such as 6-mercaptopurine (6-MP). Inherited differences in the activity of this enzyme are related to individual differences in the therapeutic efficacy and toxicity of 6-MP and other thio