Intraindividual variability in red blood cell thiopurine methyltransferase activity
β Scribed by T. Giverhaug; B. Klemetsdal; R. Lysaa; J. Aarbakke
- Book ID
- 105922515
- Publisher
- Springer
- Year
- 1996
- Tongue
- English
- Weight
- 262 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0031-6970
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π SIMILAR VOLUMES
Thiopurine methyltransferase (TPMT) catalyzes thiopurine S-methylation, an important metabolic pathway for drugs such as 6-mercaptopurine (6-MP). Inherited differences in the activity of this enzyme are related to individual differences in the therapeutic efficacy and toxicity of 6-MP and other thio
## Abstract We have examined red blood cell (RBC) thiopurine methyltransferase (TPMT) activity in a healthy population sample of Norwegian children, age 1β10 years. Boys had mean RBC TPMT activity of 11.1 Β± 2.0 U (n = 87) vs. 10.6 Β± 2.2 U (n = 71) in girls, the difference was not significant (__P__