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Thiol-dependent DNA cleavage by aminomethylated Beaucage's reagent

โœ Scribed by Zheng, Jiahui; Liu, Xiaoqian; Yuan, Qing; Shin, Yoon-Joo; Sun, Daekyu; Lu, Yixin

Book ID
118223542
Publisher
Royal Society of Chemistry
Year
2010
Tongue
English
Weight
161 KB
Volume
8
Category
Article
ISSN
1477-0520

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โœ Sandra S Matsumoto; Mathew H Sidford; Joseph A Holden; Louis R Barrows; Brent R ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 109 KB

The cytotoxic marine alkaloid ascididemin has been shown to be a thiol-dependent DNA cleaving agent. Previous mechanisms of action studies have concluded that DNA and/or the DNA processing enzyme topoisomerase II were the cellular targets for the alkaloid -this is the first direct evidence that a py