✦ LIBER ✦
Mechanism of action studies of cytotoxic marine alkaloids: ascididemin exhibits thiol-dependent oxidative DNA cleavage
✍ Scribed by Sandra S Matsumoto; Mathew H Sidford; Joseph A Holden; Louis R Barrows; Brent R Copp *
- Book ID
- 104209946
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- French
- Weight
- 109 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
The cytotoxic marine alkaloid ascididemin has been shown to be a thiol-dependent DNA cleaving agent. Previous mechanisms of action studies have concluded that DNA and/or the DNA processing enzyme topoisomerase II were the cellular targets for the alkaloid -this is the first direct evidence that a pyridoacridone alkaloid can cause DNA cleavage under physiological conditions.