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Kinetic nature of thiol activation in DNA cleavage by calicheamicin

โœ Scribed by Chatterjee, Moneesh; Cramer, Katherine D.; Townsend, Craig A.


Book ID
126300888
Publisher
American Chemical Society
Year
1993
Tongue
English
Weight
200 KB
Volume
115
Category
Article
ISSN
0002-7863

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A synthesis of the neocarzinostatin chromophore analog 2, in which the 2'-N-methylamino group of the natural product has been replaced by a hydroxyl group, is described. Thiol addition experiments in organic solvents and DNA-cleavage studies in aqueous solution are also described, and provide furthe