✦ LIBER ✦
Synthetic replacement of the methylamino group of neocarzinostatin chromophore with hydroxyl prohibits thiol activation in organic solvents and diminishes the rate and efficiency of thiol-promoted DNA cleavage in water
✍ Scribed by Andrew G. Myers; Jun Liang; Marlys Hammond
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- French
- Weight
- 316 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
A synthesis of the neocarzinostatin chromophore analog 2, in which the 2'-N-methylamino group of the natural product has been replaced by a hydroxyl group, is described. Thiol addition experiments in organic solvents and DNA-cleavage studies in aqueous solution are also described, and provide further support for the proposed participation of the carbohydrate methylamino group in neocarzinostatin activation.