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Thieno[2,3-b]furan-2-sulfonamides as topical carbonic anhydrase inhibitors

โœ Scribed by Hartman, George D.; Halczenko, Wasyl; Prugh, John D.; Smith, Robert L.; Sugrue, Michael F.; Mallorga, Pierre; Michelson, Stuart R.; Randall, William C.; Schwam, Harvey; Sondey, John M.

Book ID
121416105
Publisher
American Chemical Society
Year
1992
Tongue
English
Weight
961 KB
Volume
35
Category
Article
ISSN
0022-2623

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๐Ÿ“œ SIMILAR VOLUMES

Topically active carbonic anhydrase inhi
Topically active carbonic anhydrase inhibitors. 3. Benzofuran- and indole-2-sulfonamides
โœ Graham, Samuel L.; Hoffman, Jacob M.; Gautheron, Pierre; Michelson, Stuart R.; S ๐Ÿ“‚ Article ๐Ÿ“… 1990 ๐Ÿ› American Chemical Society ๐ŸŒ English โš– 857 KB

Derivatives of benzofuran-and indole-2-sulfonamide were prepared for evaluation as topically active ocular hypotensive agents. These compounds were found to be excellent inhibitors of carbonic anhydrase and to lower intraocular prmure in a rabbit model of ocular hypertension. However, the developmen