Synthesis of certain 5-substituted thien
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Hwang-Hsing Chen; Jesse A. May; Vincent M. Lynch
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Article
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1999
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Journal of Heterocyclic Chemistry
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English
β 669 KB
A series of the title compounds were prepared for evaluation as inhibitors of carbonic anhydrase II. Oxidation of 5-substituted thieno[2,3-b]thiophene-2-sulfonamides provided the first examples of thiophene[2,3-b]thiophene-2-sulfonamide 6,6-dioxides. These cyclic vinyl sulfones readily underwent add