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Topically active carbonic anhydrase inhibitors. 3. Benzofuran- and indole-2-sulfonamides

โœ Scribed by Graham, Samuel L.; Hoffman, Jacob M.; Gautheron, Pierre; Michelson, Stuart R.; Scholz, Thomas H.; Schwam, Harvey; Shepard, Kenneth L.; Smith, Anthony M.; Smith, Robert L.

Book ID
121489548
Publisher
American Chemical Society
Year
1990
Tongue
English
Weight
857 KB
Volume
33
Category
Article
ISSN
0022-2623

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Topically active carbonic anhydrase inhi
Topically active carbonic anhydrase inhibitors. 3. Benzofuran- and indole-2-sulfonamides
โœ Graham, Samuel L.; Hoffman, Jacob M.; Gautheron, Pierre; Michelson, Stuart R.; S ๐Ÿ“‚ Article ๐Ÿ“… 1990 ๐Ÿ› American Chemical Society ๐ŸŒ English โš– 857 KB

Derivatives of benzofuran-and indole-2-sulfonamide were prepared for evaluation as topically active ocular hypotensive agents. These compounds were found to be excellent inhibitors of carbonic anhydrase and to lower intraocular prmure in a rabbit model of ocular hypertension. However, the developmen