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Thermodynamics of Sequence-Specific Binding of PNA to DNA †

✍ Scribed by Ratilainen, Tommi; Holmén, Anders; Tuite, Eimer; Nielsen, Peter E.; Nordén, Bengt


Book ID
126894250
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
333 KB
Volume
39
Category
Article
ISSN
0006-2960

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Design of Sequence-Specific DNA-Binding
✍ Peter E. Nielsen 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 415 KB 👁 2 views

Double-stranded DNA can be viewed as a multifunctional, modular receptor that can be read sequenceselectively in a digital way (base pair per base pair) by a complementary, similarly modular ligand. This principle has been exploited in several approaches to design sequence-specific DNA-binding ligan