Design of Sequence-Specific DNA-Binding Ligands

✍ Scribed by Peter E. Nielsen

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 415 KB
• Volume: 3
• Category: Article
• ISSN: 0947-6539
• DOI: 10.1002/chem.19970030404

✦ Synopsis

Double-stranded DNA can be viewed as a multifunctional, modular receptor that can be read sequenceselectively in a digital way (base pair per base pair) by a complementary, similarly modular ligand. This principle has been exploited in several approaches to design sequence-specific DNA-binding ligands, such as triplexforming oligonucleotides, peptide nucleic acids and minor groove binding polyamides.