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Specific versus Nonspecific Binding of Cationic PNAs to Duplex DNA

✍ Scribed by Abibi, Ayome; Protozanova, Ekaterina; Demidov, Vadim V.; Frank-Kamenetskii, Maxim D.

Book ID
118516148
Publisher
Biophysical Society
Year
2004
Tongue
English
Weight
169 KB
Volume
86
Category
Article
ISSN
0006-3495

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Specific and nonspecific inhibition of t
Specific and nonspecific inhibition of transcription by DNA, PNA, and phosphorothioate promoter analog duplexes
✍ Susan E. Hamilton; Mridula Iyer; James C. Norton; David R. Corey πŸ“‚ Article πŸ“… 1996 πŸ› Elsevier Science 🌐 English βš– 277 KB

DNA duplexes analogous to the promoters for SP6 or T7 RNA polymerase inhibit transcription with exquisite selectivity. By contrast, phosphorothioate oligomers inhibit nonselectively, and peptide nucleic acid (PNA) duplexes and PNA:DNA heteroduplexes do not inhibit at all. The absence of recognition