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Thermodynamics of interaction of a fluorescent DNA oligomer with the anti-tumour drug netropsin

✍ Scribed by Naina PATEL; Helena BERGLUND; Lennart NILSSON; Rudolf RIGLER; Larry W. McLAUGHLIN; Astrid GRÄSLUND

Book ID
115129030
Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
614 KB
Volume
203
Category
Article
ISSN
1432-1327

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Chemical shifts occurring in lH nuclear magnetic resonance and Sephadex G 2.5 chromatography are used to follow the reaction of the dinucleotide C3'pSG (cytidilyl--3'phosphateS'-o,uanosine) in aqueous solution and to separate its products. Binding of the platinum occurs in first place at the cytosin