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Molecular structure of the A-tract DNA dodecamer d(CGCAAATTTGCG) complexed with the minor groove binding drug netropsin

✍ Scribed by Tabernero, Lydia; Verdaguer, Nuria; Coll, Miquel; Fita, Ignasi; van der Marel, Gijs A.; van Boom, Jacques H.; Rich, Alexander; Aymami, Joan


Book ID
120645696
Publisher
American Chemical Society
Year
1993
Tongue
English
Weight
838 KB
Volume
32
Category
Article
ISSN
0006-2960

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Accessibility of the minor groove of DNA
✍ A. F. Melnikova; A. S. Zasedatelev; A. M. Kolchinsky; G. V. Gursky; A. L. Zhuze; πŸ“‚ Article πŸ“… 1975 πŸ› Springer 🌐 English βš– 380 KB

The interaction of the antibiotics distamycin A, distamycin analogue and netropsin with chromatin of calf thymus has been studied by circular dichroism measurements and by gel filtration. The minor groove of DNA in chromatin is accessible by 83-89% to the binding of these antibiotics as compared wit