AT selectivity and DNA minor groove binding: modelling, NMR and structural studies of the interactions of propamidine and pentamidine with d(CGCGAATTCGCG)2
β Scribed by Terence C Jenkins; Andrew N Lane
- Book ID
- 114147898
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 556 KB
- Volume
- 1350
- Category
- Article
- ISSN
- 0167-4781
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π SIMILAR VOLUMES
The structures of the complexes formed between two anticancer minor-groove-binding quinolinium quaternary salts and the dodecamer d(CGCGAATTCGCG) 2 have been refined to resolutions of 1.6 and 1.8 A Λ. The complexes crystallized in space group P2 1 2 1 2 1 and the structures are isomorphous with prev
## Abstract For Abstract see ChemInform Abstract in Full Text.
## Abstract A series of six doubleβfunctionalised nucleosides, in which aromatic moieties were inserted into the 5β²β(__S__)β__C__βposition, were synthesised and incorporated into DNA duplexes. The aromatic moieties were thymineβ1βyl, phenyl, 1,2,3βtriazolβ1βyl, 1,2,3βtriazolβ4βyl, 4β(uracilβ5βyl)β1