Viscosimetric and kinetic results allow one to characterize three modes of DNA binding in the ellipticine series: ( 1 ) Ellipticine and its 9 methoxy derivative, which present maximal DNA lengthening properties and bind DNA through a single step mechanism, can be considered as pure intercalators. (
✦ LIBER ✦
Thermodynamics of drug–DNA interactions
✍ Scribed by Ihtshamul Haq
- Book ID
- 117042074
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 276 KB
- Volume
- 403
- Category
- Article
- ISSN
- 0003-9861
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Understanding the thermodynamics of drug binding to DNA is of both practical and fundamental interest. The practical interest lies in the contribution that thermodynamics can make to the rational design process for the development of new DNA targeted drugs. Thermodynamics offer key insights into the