A molecular thermodynamic view of DNA–drug interactions: a case study of 25 minor-groove binders
✍ Scribed by Saher Afshan Shaikh; Sajeedha Reshmi Ahmed; B. Jayaram
- Book ID
- 116177060
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 545 KB
- Volume
- 429
- Category
- Article
- ISSN
- 0003-9861
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📜 SIMILAR VOLUMES
## Abstract ^1^H NMR spectra of the dipiperazine‐based DNA minor groove binding compound Hoechst 32985 indicate that at room temperature and low pH (2.90) a single conformation is detected. This is attributed to the form in which both piperazine rings are protonated at the __N__‐methyl and the bulk
A series of DNA minor groove binders comprising netropsin, distamycin, the bisquaternary ammonium heterocycles SN 6999 and SN 6570, cis-diammine platinum(II)-bridged bis-netropsin, cis-diammine platinum(II)-bridged bis-distamycin and bis-glycine-linked bis-distamycin were investigated for sequencesp