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Thermodynamics and Reduction Kinetics Properties of 2-Methyl-3-hydroxypyridine-5-carboxylic Acid Oxygenase †

✍ Scribed by Chaiyen, Pimchai; Brissette, Pierre; Ballou, David P.; Massey, Vincent


Book ID
126014008
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
386 KB
Volume
36
Category
Article
ISSN
0006-2960

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Hydroxylation and Ring-Opening Mechanism
✍ Boxue Tian; Yaoquan Tu; Åke Strid; Leif A. Eriksson 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 645 KB

## Abstract Hybrid meta‐GGA density functional theory (the MPWB1K functional) was used to study the hydroxylation and ring‐opening mechanism of 2‐methyl‐3‐hydroxypyridine‐5‐carboxylic acid oxygenase (MHPCO). This enzyme catalyses the conversion of 2‐methyl‐3‐hydroxypyridine‐5‐carboxylic acid (MHPC)