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Unusual Mechanism of Oxygen Atom Transfer and Product Rearrangement in the Catalytic Reaction of 2-Methyl-3-hydroxypyridine-5-carboxylic Acid Oxygenase †

✍ Scribed by Chaiyen, Pimchai; Brissette, Pierre; Ballou, David P.; Massey, Vincent

Book ID
127158928
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
338 KB
Volume
36
Category
Article
ISSN
0006-2960

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Hydroxylation and Ring-Opening Mechanism
Hydroxylation and Ring-Opening Mechanism of an Unusual Flavoprotein Monooxygenase, 2-Methyl-3-hydroxypyridine-5-carboxylic Acid Oxygenase: A Theoretical Study
✍ Boxue Tian; Yaoquan Tu; Åke Strid; Leif A. Eriksson 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 645 KB

## Abstract Hybrid meta‐GGA density functional theory (the MPWB1K functional) was used to study the hydroxylation and ring‐opening mechanism of 2‐methyl‐3‐hydroxypyridine‐5‐carboxylic acid oxygenase (MHPCO). This enzyme catalyses the conversion of 2‐methyl‐3‐hydroxypyridine‐5‐carboxylic acid (MHPC)