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Use of 8-Substituted-FAD Analogues To Investigate the Hydroxylation Mechanism of the Flavoprotein 2-Methyl-3-hydroxypyridine-5-carboxylic Acid Oxygenase †,‡

✍ Scribed by Chaiyen, Pimchai; Sucharitakul, Jeerus; Svasti, Jisnuson; Entsch, Barrie; Massey, Vincent; Ballou, David P.

Book ID
120041990
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
149 KB
Volume
43
Category
Article
ISSN
0006-2960

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📜 SIMILAR VOLUMES

Hydroxylation and Ring-Opening Mechanism
Hydroxylation and Ring-Opening Mechanism of an Unusual Flavoprotein Monooxygenase, 2-Methyl-3-hydroxypyridine-5-carboxylic Acid Oxygenase: A Theoretical Study
✍ Boxue Tian; Yaoquan Tu; Åke Strid; Leif A. Eriksson 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 645 KB

## Abstract Hybrid meta‐GGA density functional theory (the MPWB1K functional) was used to study the hydroxylation and ring‐opening mechanism of 2‐methyl‐3‐hydroxypyridine‐5‐carboxylic acid oxygenase (MHPCO). This enzyme catalyses the conversion of 2‐methyl‐3‐hydroxypyridine‐5‐carboxylic acid (MHPC)