𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Thermal stabilization of the DNA duplex by adducts of aflatoxin B1

✍ Scribed by Indrajit Giri; Michael P. Stone

Publisher
Wiley (John Wiley & Sons)
Year
2002
Tongue
English
Weight
720 KB
Volume
65
Category
Article
ISSN
0006-3525

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Inactivation of the DNA repair gene O6-m
Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation and its relationship to aflatoxin B1-DNA adducts and p53 mutation in hepatocellular carcinoma
✍ Yu-Jing Zhang; Yu Chen; Habibul Ahsan; Ruth M. Lunn; Po-Huang Lee; Chien-Jen Che 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 French ⚖ 237 KB 👁 1 views

## Abstract O^6^‐methylguanine‐DNA methyltransferase (MGMT) is a repair protein that specifically removes promutagenic alkyl groups from the O^6^ position of guanine in DNA. __MGMT__ is transcriptionally silenced by promoter hypermethylation in several human cancers. Methylation‐specific PCR (MSP)

Stimulation of sister chromatid exchange
Stimulation of sister chromatid exchanges and mutation by aflatoxin B1-DNA adducts in Saccharomyces cerevisiae requires MEC1 (ATR), RAD53, and DUN1
✍ Michael Fasullo; Mingzeng Sun; Patricia Egner 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 171 KB

## Abstract The hepatocarcinogen aflatoxin B~1~ (AFB~1~) is a potent recombinagen but weak mutagen in the yeast __Saccharomyces cerevisiae__. AFB~1~ exposure induces DNA damage‐inducible genes, such as __RAD51__ and those encoding ribonucleotide reductase (RNR), through a __MEC1__ (ATR homolog)‐dep

Thermal stability and energetics of 15-m
Thermal stability and energetics of 15-mer DNA duplex interstrand crosslinked by trans-diamminedichloroplatinum(II)
✍ Ctirad Hofr; Viktor Brabec 📂 Article 📅 2005 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 148 KB

## Abstract The effect of the location of the interstrand cross‐link formed by __trans__‐diamminedichloroplatinum(II) (transplatin) on the thermal stability and energetics of 15‐mer DNA duplex has been investigated. The duplex containing single, site‐specific cross‐link, thermodynamically equivalen

Dose-response relationships for hepatic
Dose-response relationships for hepatic aflatoxin B1-DNA adduct formation in the rat in vivo and in vitro: The use of immunoslot blotting for adduct quantitation
✍ J.C. Phillips; S. Davies; B.G. Lake 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 106 KB 👁 2 views

An immunoslot blotting (ISB) method for quantitating aflatoxin B1-DNA adduct levels has been developed and used to examine the relationship between dose and hepatic aflatoxin B1-DNA adduct levels in rats fed aflatoxin B1 (AFB1) in the diet at dose levels of between 0.5 and 10 micrograms/kg/day. The