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The Detection and Stability of DNA Duplexes Probed by MALDI Mass Spectrometry

✍ Scribed by Rajagopalan Sudha; Renato Zenobi


Publisher
John Wiley and Sons
Year
2002
Tongue
German
Weight
79 KB
Volume
85
Category
Article
ISSN
0018-019X

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## Abstract The geometries of a 13β€…mer of a DNA double helix (5′‐GCGTAC**A**CATGCG‐3β€²) were determined by molecular dynamics simulations using a Cornell etβ€…al. empirical force field. The bases in the central base pair (shown in bold) were replaced (one or both) by a series of hydrophobic base analo