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Thermal rearrangement of the immunosuppressant FK-506

โœ Scribed by H. Ok; B.H. Arison; R.G. Ball; T.R. Beattie; M.H. Fisher; M.J. Wyvratt

Publisher
Elsevier Science
Year
1990
Tongue
French
Weight
218 KB
Volume
31
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

Treatment of FK-506 in xylene at rcflux results in a 13.31 sigmatropic

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โœ M. Furber; M.E. Cooper; D.K. Donald ๐Ÿ“‚ Article ๐Ÿ“… 1993 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 187 KB

Beckmann rearrangement of FK506 E-oxime gave amide 2 and the fragmentation product 4. Compound 4 was atso prepared by total synthesis. The immunosuppressant FK506 has been the subject of considerabie synthetic' and degradative2 studies. As part of our pmgramme in this area we investigated the stNdU