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Mechanism of the inhibition of T cell activation by immunosuppressant FK506

✍ Scribed by S. Sakuma; H. Kosaka; C. Kiyotaki; T. Fujitsu; H. Senoh; T. Hamaoka; H. Fujiwara

Publisher: Elsevier Science
Year: 1988
Tongue: English
Weight: 71 KB
Volume: 10
Category: Article
ISSN: 0192-0561
DOI: 10.1016/0192-0561(88)90427-4

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## Abstract The effects of the immunosuppressants cyclosporin A (CsA), FK506 and rapamycin have been compared using murine B cells activated with a variety of mitogens. FK506 is a macrolide antibiotic that has been recently shown to inhibit T cell activation by a mechanism that appears similar to t