Thermal Isomerization of Bicyclo[3.2.0]hept-6-en-2-ols 1
β Scribed by Cargill, Robert L.; Pond, David M.
- Book ID
- 126097926
- Publisher
- American Chemical Society
- Year
- 1966
- Tongue
- English
- Weight
- 267 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0022-3263
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π SIMILAR VOLUMES
The thermal isomerization of 6-difluoromethylenebicyclo[3.2.0]hept-2-ene proceec via two competing 1,3-sigmatropic processes, with an E, nearly identical to that of the hydrocarbon. Sigmatropic isomerizations of the 6-methylenebicyclo[3.2.O]hept-2-ene system have been examined extensively by Hasselm
Single crystal X-ray diffraction analysis of compounds A, B and, C helped us to assign the absolute configurations of the enantiomers of the bicyclo[3.2.0]hept-3-en-6-endo-ols 4-6. These bicyclic alcohols were easily obtained by: (i) stereoselective reductions of the bicyclo[3.2.0]hept-3-en-6-ones 1
## Abstract The chemistry of the highly substituted cyclobutanone derivative 2, which is easily accessible from 1, is dominated by the steric hindrance caused by the substitutents: Reduction with hydride reagents and nucleophilic additions with methyllithium are less stereoselective than correspond