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Therapy of chronic hepatitis b with recombinant human alpha and gamma interferon

✍ Scribed by Adrian M. Di Bisceglie; Vinod K. Rustgi; Chris Kassianides; Mauricio Lisker-Melman; Yoon Park; Jeanne G. Waggoner; Jay H. Hoofnagle

Publisher: John Wiley and Sons
Year: 1990
Tongue: English
Weight: 584 KB
Volume: 11
Category: Article
ISSN: 0270-9139
DOI: 10.1002/hep.1840110217

No coin nor oath required. For personal study only.

✦ Synopsis

Eight patients with chronic hepatitis B entered a pilot study of gamma interferon and alpha interferon in combination. Gamma interferon alone had minimal inhibitory effects on serum levels of hepatitis B virus as monitored by serum HBV DNA and DNA-polymerase activity. The drug also gave troublesome side effects. In contrast, alpha interferon had more potent inhibitory effects on serum HBV levels and fewer side effects. When combined, the two interferons showed no additive or synergistic effects in inhibiting serum levels of HBV DNA or DNA polymerase. These findings indicate that the addition of gamma interferon to alpha interferon provides no additional antiviral effects but contributes significantly to side effects. (HEPATOLOGY 1990;11:266-270.

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