Recombinant interferon alfa (r-IFNa2) has been shown to normalize the aminotransferase levels in approximately 50% of patients with chronic hepatitis C virus (HCV). Few patients experience a relapse during the treatment, in spite of a complete initial response (breakthrough). We studied 191 HCV Ab-p
Recombinant interferon-alfa therapy in children with chronic hepatitis C
β Scribed by Flavia Bortolotti; Raffaella Giacchino; Pietro Vajro; Cristiana Barbera; Carlo Crivellaro; Alfredo Alberti; Gabriella Nebbia; Lucia Zancan; Lorena de Moliner; Adalberto Bertolini; Fiorella Balli; Francesco Callea
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 642 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0270-9139
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Treatment of patients with chronic hepatitis C has had limited success because of relapses and nonresponse to interferon alfa therapy (currently the only established therapeutic agent). A retrospective study was done to determine the efficacy of re-treatment with interferon and the predictors of res
Twelve children with chronic non-A, non-B hepatitis were entered in a pilot trial of recombinant interferon-alpha. Although all the children had hepatitis C virus RNA in serum, only five had antibodies against this virus. Children received 3 MU/m2 body surface area interferon-alpha 3 times/wk for 6
## Predictors of a Sustained Beneficial Response to Interferon Alfa Therapy in Chronic Hepatitis C Interferon alfa was first reported to have beneficial effects in chronic hepatitis C in the mid-l980s,' effects that were subsequently verified in multiple randomized controlled trials performed in