✦ LIBER ✦

Production of interferon alpha and interferon gamma by peripheral blood leukocytes from patients with chronic hepatitis B virus infection

✍ Scribed by Dr. Jochen Abb; Vera Zachoval; Friedrich Deinhardt; Gerd R. Pape; Reinhart Zachoval; Josef Eisenburg

Publisher: John Wiley and Sons
Year: 1985
Tongue: English
Weight: 324 KB
Volume: 16
Category: Article
ISSN: 0146-6615
DOI: 10.1002/jmv.1890160209

No coin nor oath required. For personal study only.

✦ Synopsis

Peripheral blood leukocytes from patients with chronic hepatitis B virus (HBV) infection were studied for their capacity to produce interferon (IFN) alpha or IFN gamma. Yields of IFN alpha in leukocyte cultures stimulated with influenza A virus or human leukemic cells were significantly lower than those obtained from healthy controls. Production of IFN gamma in response to induction with protein A of Staphylococcus aureus was also significantly diminished. Defects of IFN production in leukocyte cultures showed no correlation with active viral replication or the degree of severity of HBV-associated liver disease. The demonstration of partial defects of endogenous IFN production provides a rationale for using IFN replacement therapy in patients with chronic HBV infection.

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