Therapy of acute promyelocytic leukemia with all-trans retinoic acid
โ Scribed by Gillis, S.; Ben-Yehuda, D.; Rachmilewitz, E.A.
- Book ID
- 122798521
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 146 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0959-8049
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๐ SIMILAR VOLUMES
Background. Differentiation therapy with all-trans retinoic acid (RA) induces more than 80% complete remission with the least complications in patients with acute promyelocytic leukemia (APL). The authors studied the cost-benefit of this new treatment modality compared with conventional chemotherapy
A 22-year-old female presented with acute promyelocytic leukemia (APL). Treatment with all-trans retinoic acid (ATRA) resulted in a severe exacerbation of the coagulopathy 5 days after its introduction. This was complicated by bone marrow necrosis, parenchymal liver damage and acute tubular necrosis