A 22-year-old female presented with acute promyelocytic leukemia (APL). Treatment with all-trans retinoic acid (ATRA) resulted in a severe exacerbation of the coagulopathy 5 days after its introduction. This was complicated by bone marrow necrosis, parenchymal liver damage and acute tubular necrosis
β¦ LIBER β¦
Hypercalcemia due to an interaction of all-trans retinoic acid (ATRA) and itraconazole therapy for acute promyelocytic leukemia successfully treated with zoledronic acid
β Scribed by R. Cordoba; E. Ramirez; S. H. Lei; A. Lopez de la Guia; M. J. Sanjurjo; A. J. Carcas; F. Hernandez-Navarro
- Publisher
- Springer
- Year
- 2008
- Tongue
- English
- Weight
- 56 KB
- Volume
- 64
- Category
- Article
- ISSN
- 0031-6970
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## Abstract The use of arsenic trioxide (As~2~O~3~, ATO) combined with allβtrans retinoic acid (ATRA) has recently been reported to induce remission in patients with acute promyelocytic leukemia (APL). However, its efficiency remains inconclusive mainly due to the small number of the available case