𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Therapy and prevention of arthritis by recombinant adeno-associated virus vector with delivery of interleukin-1 receptor antagonist

✍ Scribed by Ru-Yu Pan; Show-Li Chen; Xiao Xiao; Dai-Wei Liu; Ho-Jeng Peng; Yeou-Ping Tsao

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
840 KB
Volume
43
Category
Article
ISSN
0004-3591

No coin nor oath required. For personal study only.

πŸ“œ SIMILAR VOLUMES

Intra-articular gene delivery and expres
Intra-articular gene delivery and expression of interleukin-1Ra mediated by self-complementary adeno-associated virus
✍ Jesse D. Kay; Elvire Gouze; Thomas J. Oligino; Jean-Noel Gouze; Rachael S. Watso πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 269 KB

## Abstract ## Background The adeno‐associated virus (AAV) has many safety features that favor its use in the treatment of arthritic conditions; however, the conventional, single‐stranded vector is inefficient for gene delivery to fibroblastic cells that primarily populate articular tissues. This

Prevention of murine collagen-induced ar
Prevention of murine collagen-induced arthritis in the knee and ipsilateral paw by local expression of human interleukin-1 receptor antagonist protein in the knee
✍ Andrew C. Bakker; Leo A. B. Joosten; Onno J. Arntz; Monique M. A. Helsen; Alison πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 925 KB

Objective. To determine the efficacy of local human interleukin-1 receptor antagonist (HuIL-1Ra) gene therapy in murine collagen-induced arthritis (CIA). Methods. DBN1 mice were immunized against bovine type I1 collagen. Before the onset of arthritis, NIH/3T3 fibroblasts transfected with pMFG-IRAP