Therapeutic vaccines: challenges of chronic viral infections
✍ Scribed by Matti Sällberg; Malin Weiland; Lars Frelin
- Book ID
- 119226123
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 490 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1740-6773
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## Abstract There are several lines of evidence suggesting that specific vaccine therapy with a standard hepatitis B virus (HBV) vaccination reduces HBV replication. The aim of this study was to investigate the anti‐viral mechanism of vaccine therapy in chronic hepatitis B patients. Nineteen patien
The goal of therapeutic vaccination is to elicit an antiviral immune response within persistently infected individuals and consequently eradicate the infection. CD8+ T cells are potent mediators of viral clearance; however, during chronic infections CD4+ T cell help is required to sustain antiviral